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KMID : 1123920100240020258
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 2 p.258 ~ p.265
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( Anti-inflammatory Effects of Effective Microorganism Fermentation Substance on Atopic Dermatitis-like NC/Nga Mouse Model )
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Mok Ji-Ye
Chang Won-Ghil
Moon Byung-Eun
Park Kwang-Hyun
Jang Seon-Il
Jeong Seung-Il
Cho Jung Keun
Choi Ji-Won
Nam Sang-Yun
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Abstract
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Atopic dermatitis (AD) is a chronically relapsing pruritic inflammatory skin disease. To find new anti-inflammatory products for skin inflammatory disease such as AD and contact dermatitis, we produced the effective microorganism fermentation substance (EM-S) by fermentation of medicinal plants with effective microorganisms including photosynthetic bacteria, lactic acid bacteria and yeast, screened the effects of EM-S on NC/Nga model mice. Murine AD-like skin lesions were made by painting Dermatophagoides farinae (Df) extract. Topically applied EM-S significantly reduced clinical severity score, ear thickness and histological grade in AD-like NC/Nga mouse model by Df antigen sensitization. In addition, the serum IgE and Th2 chemokine levels (TARC/CCL17, MDC/CCL22 and CTACK/CCL27) were significantly reduced by EM-S. Futhermore, skin tissue expressions of Th2 chemokines were significantly reduced by EM-S. These results demonstrate that topical application of EM-S may be improve the AD-like skin lesion by suppressing IgE and Th2 chemokines.
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KEYWORD
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atopic dermatitis, Dermatophagoides farinae (Df), EM-S, IgE, Th2 chemokines
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